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DeCS
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Descriptor English:
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Protein Tyrosine Phosphatase, Non-Receptor Type 22
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Descriptor Spanish:
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Proteína Tirosina Fosfatasa no Receptora Tipo 22
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Descriptor Portuguese:
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Proteína Tirosina Fosfatase não Receptora Tipo 22
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Synonyms English:
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Lymphoid Phosphatase
Lyp1 PTPase
Lyp2 PTPase
PTPN 22 Protein
PTPN-22 Protein
PTPase Lyp
PTPase, Lyp1
PTPase, Lyp2
Protein Tyrosine Phosphatase Lyp
Protein Tyrosine Phosphatase, Non Receptor Type 22
Protein-Tyrosine Phosphatase Lyp
Tyrosine Protein Phosphatase, Non Receptor Type 22
Tyrosine Protein Phosphatase, Non-Receptor Type 22
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Tree Number:
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D08.811.277.352.650.775.300.930
D12.644.360.585.930
D12.776.476.564.930
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Definition English:
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A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES. |
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History Note English:
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2008(1999)
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Allowable Qualifiers English:
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Record Number:
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52703
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Unique Identifier:
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D054596
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Occurrence in VHL:
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Similar:
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DeCS
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